Product ID:CYTOXAN TABLETS 25 MG.
MSDS Date:03/01/1990
FSC:6505
NIIN:01-083-8121
MSDS Number: BKYRW

Emergency Phone: (812) 429-5678 OR (812) 429-5000

Info Phone: (812) 429-5678 OR (812) 429-5000

Cage: DO726

Telephone: 812-429-5140

Cage: DO726

CYCLOPHOSPHAMIDE HYDRATE

CAS: 6055-19-2

RTECS: RP6157750

Fraction By Weight: 9%

LD50 LC50 Mixture:ORAL LD50 (RAT): 1045 MG/KG.
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:EYES: CONJUNCTIVITIS. SKIN: ABSORPTION
& SENSITIZATION. INGESTION: CYTOTOXIC AGENT, BONE MARROW
SUPPRESSION, GENITO-URINARY, LUNG, CARDIAC & GASTROINTESTINAL
TOXICITY.
Explanation of Carcinogenicity:HUMAN POSITIVE
Effects of Overexposure:EYES: CONJUNCTIVITIS. SKIN: ABSORPTION &
SENSITIZATION. INGESTION: CYTOTOXIC AGENT, BONE MARROW SUPPRESSION,
GENITO-URINARY, LUNG, CARDIAC & GASTROINTESTINAL TOXICITY.

First Aid:EYES: FLUSH W/PLENTY OF WATER FOR 15 MIN. SKIN: WASH W/SOAP &
WATER. INGESTION/INHALATION: OBTAIN MEDICAL ATTENTION IN ALL CASES.

Extinguishing Media:WATER, CO2 & DRY CHEMICAL
Fire Fighting Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS & FULL
PROTECTIVE CLOTHING.

Spill Release Procedures:SCOOP UP TABLETS & PLACE IN SUITABLE
CONTAINER. IF TABLETS ARE CRUSHED, CLEAN UP LARGER PIECES, CLEAN
REMAINING POWDER W/DAMP CLOTH TOWELS TO SUPPRESS DUST. CLEAN
W/DETERGENT & WATER.

Handling and Storage Precautions:STORE AT TEMPERATURES 77F & BELOW.
AVOID CUTS FROM GLASS IF BOTTLES BREAK.

Respiratory Protection:USE NIOSH APPROVED DUST RESPIRATOR IF >TLV.
Ventilation:LOCAL EXHAUST TO MAINTAIN Protective Gloves:SURGICAL LATEX
Eye Protection:NOT NORMALLY NECESSARY
Work Hygienic Practices:WASH HANDS BEFORE EATING OR SMOKING.
Supplemental Safety and Health
MEDICAL SURVEILLANCE: PREPLACEMENT PHYSICAL EAMINATION & HISTORY, CBC,
W/DIFFERENTIAL, TO PROVIDE BASELINE.

Melt/Freeze Pt:M.P/F.P Text:105.8-113F
Solubility in Water:20 MG/ML
Appearance and Odor:WHITE TABLET W/BLUE SPECKS

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:HEAT & TEMPERATURES >77F
Hazardous Decomposition Products:TOXIC FUMES OF CHLORINE, OXIDES OF
NITROGEN & PHOSPHORUS
Conditions to Avoid Polymerization:TEMPERATURES >120F.

Waste Disposal Methods:DISPOSAL BY INCINERATION IN COMPLIANCE W/LOCAL,
STATE, & FEDERAL REGULATIONS. U058 (HAZARDOUS WASTE).

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.